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2016 Jun;46(6):747-9

Interestingly, systemic delivery of GGsTop at a single time inhibited serum GGT activity in a dose dependent manner and to a greater degree than airway delivery

Acerbi, I., Cassereau, L., Dean, I., Shi, Q., Au, A., Park, C., et al

Rather than dissolving immediately upon contact with gastric fluid, the capsule protects its contents until reaching the small intestine

Specifically, intestinal dysbiosis results in the loss of the gut barrier integrity that allows lipopolysaccharide (LPS) translocation from bacteria into circulation where LPS acts as a ligand-dependent toll-like receptor 4 (TLR4) stimulator initiating downstream signaling cascades amplifying the systemic inflammatory cascade (Longo et al., 2024)

& Rakov, H